- Most effective when started at the onset of bleeding.
- Only use for the shortest duration necessary.
- Tell your doctor if you're not seeing improvement after 3 cycles.
- Let your doctor know about any kidney/liver history.
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Proper Packaging
Enclot 650 is an anti-fibrinolytic agent. It works by blocking the breakdown of blood clots. Specifically, it inhibits the binding of plasminogen and plasmin to fibrin, thus stabilizing blood clots and helping to reduce or prevent excessive bleeding. If you miss a dose, skip it and continue with the next scheduled dose. Do not double the dose.
Headache (50%)
Nasal or sinus congestion (25%)
Back pain (21%)
Abdominal pain (20%)
Bone/muscle/joint pain (11%)
Joint pain, muscle cramps
Migraine
Anemia
Fatigue
Visual changes
Hypotension (especially with rapid IV use)
Nausea, vomiting, diarrhea
Oral: 1–1.5 g or 15–25 mg/kg twice or three times daily.
Hereditary angioedema: 1–1.5 g twice or three times daily.
IV: 0.5–1 g or 10 mg/kg three times daily, or 25–50 mg/kg/day by continuous infusion.
Oral/IV for bleeding or angioedema: 25 mg/kg twice or three times daily.
IV (short-term hemorrhage): 10 mg/kg two or three times daily.
Adjust according to serum creatinine:
120–250 micromol/L: 15 mg/kg twice daily
250–500 micromol/L: 15 mg/kg once daily
>500 micromol/L: 7.5 mg/kg once daily or 15 mg/kg every 48 hours
Potentially Fatal Interactions:
Estrogens, Factor IX concentrates, or anti-inhibitor coagulant concentrates may increase the risk of clot formation.
Tretinoin (used in acute promyelocytic leukemia) may raise the risk of fatal thrombotic events.
Store below 30°C, away from light and moisture.
Keep out of children's reach.
After reconstitution or dilution (if injectable form used), store at 2–8°C and discard after 72 hours if unused.
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