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Enclot 650 Tablet 1 Strip
Enclot 650 – Tranexamic Acid
- Bleeding disorders, including heavy menstrual bleeding, nosebleeds, and post-operative bleeding
- Hereditary angioedema
- Short-term treatment of haemorrhage
- Most effective when started at the onset of bleeding.
- Only use for the shortest duration necessary.
- Tell your doctor if you're not seeing improvement after 3 cycles.
- Let your doctor know about any kidney/liver history.
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✅ Description:
Enclot 650 is an anti-fibrinolytic agent. It works by blocking the breakdown of blood clots. Specifically, it inhibits the binding of plasminogen and plasmin to fibrin, thus stabilizing blood clots and helping to reduce or prevent excessive bleeding. If you miss a dose, skip it and continue with the next scheduled dose. Do not double the dose.
- Use cautiously in patients with mild to moderate renal dysfunction, irregular menstrual cycles, or a history of blood clots.
- Avoid rapid IV injection (>1 mL/min) to prevent low blood pressure.
- Monitor liver function and perform eye exams during prolonged therapy.
- Discontinue if color vision changes are detected.
- Use cautiously during pregnancy and breastfeeding.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Side Effects
Very Common (>10%)
Headache (50%)
Nasal or sinus congestion (25%)
Back pain (21%)
Abdominal pain (20%)
Bone/muscle/joint pain (11%)
Common (1–10%)
Joint pain, muscle cramps
Migraine
Anemia
Fatigue
Unknown Frequency
Visual changes
Hypotension (especially with rapid IV use)
Nausea, vomiting, diarrhea
✔️ Dosage & Administration
General Instruction
- Take exactly as prescribed.
- Swallow the tablet whole with food.
- Do not crush, chew, or break it.
Adults
Oral: 1–1.5 g or 15–25 mg/kg twice or three times daily.
Hereditary angioedema: 1–1.5 g twice or three times daily.
IV: 0.5–1 g or 10 mg/kg three times daily, or 25–50 mg/kg/day by continuous infusion.
Children
Oral/IV for bleeding or angioedema: 25 mg/kg twice or three times daily.
IV (short-term hemorrhage): 10 mg/kg two or three times daily.
Renal Dose Adjustment
Adjust according to serum creatinine:
120–250 micromol/L: 15 mg/kg twice daily
250–500 micromol/L: 15 mg/kg once daily
>500 micromol/L: 7.5 mg/kg once daily or 15 mg/kg every 48 hours
✔️ Drug Interactions
Potentially Fatal Interactions:
Estrogens, Factor IX concentrates, or anti-inhibitor coagulant concentrates may increase the risk of clot formation.
Tretinoin (used in acute promyelocytic leukemia) may raise the risk of fatal thrombotic events.
✔️ Contraindications
- Severe renal impairment
- Ongoing intravascular clotting or thromboembolic disease
- Disturbances in color vision
- Subarachnoid hemorrhage
✔️ Storage Conditions
Store below 30°C, away from light and moisture.
Keep out of children's reach.
After reconstitution or dilution (if injectable form used), store at 2–8°C and discard after 72 hours if unused.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
